Design and Optimizing of On-Chip Kinesin Substrates for Molecular Communication

Lab-on-chip devices and point-of-care diagnostic chip devices are composed of many different components such as nanosensors that must be able to communicate with other components within the device. Molecular communication is a promising solution for on-chip communication. In particular, kinesin driven microtubule (MT) motility is an effective means of transferring information particles from one component to another. However, finding an optimal shape for these channels can be challenging. In this paper we derive a mathematical optimization model that can be used to find the optimal channel shape and dimensions for any transmission period. We derive three specific models for the rectangular channels, regular polygonal channels, and regular polygonal ring channels. We show that the optimal channel shapes are the square-shaped channel for the rectangular channel, and circular-shaped channel for the other classes of shapes. Finally, we show that among all 2 dimensional shapes the optimal design choice that maximizes information rate is the circular-shaped channel.Comment: accepted for publication in IEEE Transactions on Nanotechnolog

Capacity of Molecular Channels with Imperfect Particle-Intensity Modulation and Detection

This work introduces the particle-intensity channel (PIC) as a model for molecular communication systems and characterizes the properties of the optimal input distribution and the capacity limits for this system. In the PIC, the transmitter encodes information, in symbols of a given duration, based on the number of particles released, and the receiver detects and decodes the message based on the number of particles detected during the symbol interval. In this channel, the transmitter may be unable to control precisely the number of particles released, and the receiver may not detect all the particles that arrive. We demonstrate that the optimal input distribution for this channel always has mass points at zero and the maximum number of particles that can be released. We then consider diffusive particle transport, derive the capacity expression when the input distribution is binary, and show conditions under which the binary input is capacity-achieving. In particular, we demonstrate that when the transmitter cannot generate particles at a high rate, the optimal input distribution is binary.Comment: Accepted at IEEE International Symposium on Information Theory (ISIT